Baicalin attenuates fibrogenic process in human renal proximal tubular cells (HK-2) exposed to diabetic milieu.

Nam, Jung Eun; Jo, So Yeon; Ahn, Chul Woo; Kim, Yu Sik

Nam, Jung Eun; Jo, So Yeon; Ahn, Chul Woo; Kim, Yu Sik.

Afiliação

Nam JE; Brain Korea 21 PLUS Project for medical Science, Yonsei University, Seoul, Republic of Korea.
Jo SY; Department of Medicine, the Graduate school of Yonsei University, Seoul, Republic of Korea.
Ahn CW; Severance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, Seoul, Republic of Korea; Division of Endocrinology, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Kim YS; Severance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address: cromoton@yuhs.ac.

Life Sci ; 254: 117742, 2020 Aug 01.

Article em En | MEDLINE | ID: mdl-32360619

Assuntos

Diabetes Mellitus Tipo 2/patologia; Flavonoides/farmacologia; Túbulos Renais Proximais/efeitos dos fármacos; Adulto; Linhagem Celular; Diabetes Mellitus Tipo 2/genética; Diabetes Mellitus Tipo 2/metabolismo; Expressão Gênica; Humanos; Inflamação/metabolismo; Túbulos Renais Proximais/patologia; Masculino; Proteínas/metabolismo

Palavras-chave

Baicalin; Diabetic nephropathy; Fibrosis; GABA(A)R; Inflammation; JAK/STAT; NF-κB; Proximal tubular epithelial cell

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Flavonoides / Diabetes Mellitus Tipo 2 / Túbulos Renais Proximais Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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