The effects of concentric and eccentric training in murine models of dysferlin-associated muscular dystrophy.
Muscle Nerve
; 62(3): 393-403, 2020 09.
Article
em En
| MEDLINE
| ID: mdl-32363622
ABSTRACT
INTRODUCTION:
Dysferlin-deficient murine muscle sustains severe damage after repeated eccentric contractions.METHODS:
With a robotic dynamometer, we studied the response of dysferlin-sufficient and dysferlin-deficient mice to 12 weeks of concentrically or eccentrically biased contractions. We also studied whether concentric contractions before or after eccentric contractions reduced muscle damage in dysferlin-deficient mice.RESULTS:
After 12 weeks of concentric training, there was no net gain in contractile force in dysferlin-sufficient or dysferlin-deficient mice, whereas eccentric training produced a net gain in force in both mouse strains. However, eccentric training induced more muscle damage in dysferlin-deficient vs dysferlin-sufficient mice. Although concentric training produced minimal muscle damage in dysferlin-deficient mice, it still led to a prominent increase in centrally nucleated fibers. Previous exposure to concentric contractions conferred slight protection on dysferlin-deficient muscle against damage from subsequent injurious eccentric contractions.DISCUSSION:
Concentric contractions may help dysferlin-deficient muscle derive the benefits of exercise without inducing damage.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Condicionamento Físico Animal
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Músculo Esquelético
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Distrofia Muscular do Cíngulo dos Membros
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Disferlina
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Contração Muscular
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article