Towards a Quantitative Mechanistic Understanding of Localized Pulmonary Tissue Retention-A Combined In Vivo/In Silico Approach Based on Four Model Drugs.

Himstedt, Anneke; Braun, Clemens; Wicha, Sebastian Georg; Borghardt, Jens Markus

Himstedt, Anneke; Braun, Clemens; Wicha, Sebastian Georg; Borghardt, Jens Markus.

Afiliação

Himstedt A; Department of Clinical Pharmacy, Institute of Pharmacy, University of Hamburg, 20146 Hamburg, Germany.
Braun C; Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.
Wicha SG; Drug Discovery Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397 Biberach, Germany.
Borghardt JM; Department of Clinical Pharmacy, Institute of Pharmacy, University of Hamburg, 20146 Hamburg, Germany.

Pharmaceutics ; 12(5)2020 Apr 29.

Article em En | MEDLINE | ID: mdl-32365674

Palavras-chave

alveolar; bronchi; lung concentration; lung retention; pharmacokinetics; pulmonary blood flow; semi-mechanistic PK modelling; tissue affinity; trachea

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article