Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells.
J Exp Med
; 217(7)2020 07 06.
Article
em En
| MEDLINE
| ID: mdl-32374402
ABSTRACT
Cytotoxic T cells play a key role in adaptive immunity by killing infected or cancerous cells. While the transcriptional control of CD8 T cell differentiation and effector function following T cell activation has been extensively studied, little is known about epigenetic regulation of these processes. Here we show that the histone deacetylase HDAC3 inhibits CD8 T cell cytotoxicity early during activation and is required for persistence of activated CD8 T cells following resolution of an acute infection. Mechanistically, HDAC3 inhibits gene programs associated with cytotoxicity and effector differentiation of CD8 T cells including genes encoding essential cytotoxicity proteins and key transcription factors. These data identify HDAC3 as an epigenetic regulator of the CD8 T cell cytotoxicity program.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T Citotóxicos
/
Linfócitos T CD8-Positivos
/
Epigênese Genética
/
Histona Desacetilases
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article