Blood microparticles are a component of immune modulation in red blood cell transfusion.

Pinheiro, Marion Klea; Tamagne, Marie; Elayeb, Rahma; Andrieu, Muriel; Pirenne, France; Vingert, Benoît

Pinheiro, Marion Klea; Tamagne, Marie; Elayeb, Rahma; Andrieu, Muriel; Pirenne, France; Vingert, Benoît.

Afiliação

Pinheiro MK; Etablissement Français du Sang, Ile-de-France, France.
Tamagne M; Institut Mondor de Recherche Biomédicale, lnserm U955, Equipe Pirenne, Créteil, France.
Elayeb R; Laboratory of Excellence GR-Ex, Paris, France.
Andrieu M; Université Paris-Est, Créteil, France.
Pirenne F; Etablissement Français du Sang, Ile-de-France, France.
Vingert B; Institut Mondor de Recherche Biomédicale, lnserm U955, Equipe Pirenne, Créteil, France.

Eur J Immunol ; 50(8): 1237-1240, 2020 08.

Article em En | MEDLINE | ID: mdl-32379351

ABSTRACT

ABSTRACT

Patients may display alloimmunization following transfusion. Microparticles (MPs) released into the blood are present in transfusion products. We show that MPs can modulate the immune system, CD4+ T-cell, and humoral responses, through their concentration, cellular origin and phenotype, and should therefore be considered to reduce the immune impact of transfusion.

Assuntos

Micropartículas Derivadas de Células/fisiologia; Transfusão de Eritrócitos; Eritrócitos/imunologia; Imunomodulação; Animais; Citocinas/fisiologia; Humanos; Camundongos

Palavras-chave

Alloimmunization; Blood extracellular vesicles; CD4+ T-cell response

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transfusão de Eritrócitos / Eritrócitos / Micropartículas Derivadas de Células / Imunomodulação Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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