Tcf1+ cells are required to maintain the inflationary T cell pool upon MCMV infection.
Nat Commun
; 11(1): 2295, 2020 05 08.
Article
em En
| MEDLINE
| ID: mdl-32385253
ABSTRACT
Cytomegalovirus-based vaccine vectors offer interesting opportunities for T cell-based vaccination purposes as CMV infection induces large numbers of functional effector-like cells that accumulate in peripheral tissues, a process termed memory inflation. Maintenance of high numbers of peripheral CD8 T cells requires continuous replenishment of the inflationary T cell pool. Here, we show that the inflationary T cell population contains a small subset of cells expressing the transcription factor Tcf1. These Tcf1+ cells resemble central memory T cells and are proliferation competent. Upon sensing viral reactivation events, Tcf1+ cells feed into the pool of peripheral Tcf1- cells and depletion of Tcf1+ cells hampers memory inflation. TCR repertoires of Tcf1+ and Tcf1- populations largely overlap, with the Tcf1+ population showing higher clonal diversity. These data show that Tcf1+ cells are necessary for sustaining the inflationary T cell response, and upholding this subset is likely critical for the success of CMV-based vaccination approaches.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
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Muromegalovirus
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Infecções por Herpesviridae
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Fator 1 de Transcrição de Linfócitos T
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article