Lysine succinylation and SIRT5 couple nutritional status to glutamine catabolism.

Lukey, Michael J; Greene, Kai Su; Cerione, Richard A

Lukey, Michael J; Greene, Kai Su; Cerione, Richard A.

Afiliação

Lukey MJ; Department of Molecular Medicine, Cornell University, Ithaca, NY, USA.
Greene KS; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Cerione RA; Department of Molecular Medicine, Cornell University, Ithaca, NY, USA.

Mol Cell Oncol ; 7(3): 1735284, 2020.

Article em En | MEDLINE | ID: mdl-32391426

ABSTRACT

ABSTRACT

The metabolic microenvironment of tumors is characterized by fluctuating and limited nutrient availability. To survive these conditions, cancer cell-intrinsic mechanisms sense and signal nutritional status. We describe how glutaminase (GLS) is destabilized by lysine succinylation and stabilized by the NAD+-dependent desuccinylase sirtuin 5 (SIRT5), coupling nutrient levels to metabolic flux.

Palavras-chave

GLS; SIRT5; cancer-metabolism; glutamine; succinylation

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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