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A new SIRT1 inhibitor, MHY2245, induces autophagy and inhibits energy metabolism via PKM2/mTOR pathway in human ovarian cancer cells.
Tae, In Hwan; Son, Ji Yeon; Lee, Su Hyun; Ahn, Mi-Young; Yoon, Kyungsil; Yoon, Sungpil; Moon, Hyung Ryong; Kim, Hyung Sik.
Afiliação
  • Tae IH; School of Pharmacy, Sungkyunkwan University, 2066, Seobu-ro, Suwon 16419, Republic of Korea.
  • Son JY; School of Pharmacy, Sungkyunkwan University, 2066, Seobu-ro, Suwon 16419, Republic of Korea.
  • Lee SH; School of Pharmacy, Sungkyunkwan University, 2066, Seobu-ro, Suwon 16419, Republic of Korea.
  • Ahn MY; Major in Pharmaceutical Engineering, Division of Bio-industry, College of Medical and Life Sciences, Silla University, Busan 46958, Republic of Korea.
  • Yoon K; Comparative Biomedicine Research Branch, Division of Translational Science, National Cancer Center, 323 Ilsandong-gu, Goyang-si, Gyeonggi-do, 10408, Republic of Korea.
  • Yoon S; School of Pharmacy, Sungkyunkwan University, 2066, Seobu-ro, Suwon 16419, Republic of Korea.
  • Moon HR; College of Pharmacy, Pusan National University, Busandaehak-ro 63, Geumjeong-gu, Busan 46241, Republic of Korea.
  • Kim HS; School of Pharmacy, Sungkyunkwan University, 2066, Seobu-ro, Suwon 16419, Republic of Korea.
Int J Biol Sci ; 16(11): 1901-1916, 2020.
Article em En | MEDLINE | ID: mdl-32398958
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Hormônios Tireóideos / Proteínas de Transporte / Metabolismo Energético / Sirtuína 1 / Proteínas de Membrana / Antineoplásicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Hormônios Tireóideos / Proteínas de Transporte / Metabolismo Energético / Sirtuína 1 / Proteínas de Membrana / Antineoplásicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article