Gene of the month: APOL1.
J Clin Pathol
; 73(8): 441-443, 2020 Aug.
Article
em En
| MEDLINE
| ID: mdl-32404472
ABSTRACT
Apolipoprotein L1 (APOL1) is a protein encoded by the APOL1 gene, found only in humans and several primates. Two variants encoding two different isoforms exist for APOL1, namely G1 and G2. These variants confer increased protection against trypanosome infection, and subsequent African sleeping sickness, and also increase the likelihood of renal disease in individuals of African ancestry. APOL1 mutations are associated with increased risk of chronic kidney disease, inflammation, and exacerbation of systemic lupus erythematosus-associated renal dysfunction. This review serves to outline the structure and function of APOL1, as well as its role in several disease outcomes.
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Base de dados:
MEDLINE
Assunto principal:
Apolipoproteína L1
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article