Epidemiology of Escherichia coli Bacteremia: A Systematic Literature Review.
Clin Infect Dis
; 72(7): 1211-1219, 2021 04 08.
Article
em En
| MEDLINE
| ID: mdl-32406495
ABSTRACT
BACKGROUND:
Escherichia coli is the most common cause of bacteremia in high-income countries. To enable the development and implementation of effective prevention strategies, a better understanding of the current epidemiology of invasive E. coli infections is needed.METHODS:
A systematic review of literature published between 1 January 2007 and 31 March 2018 on the burden and epidemiology of E. coli bacteremia in populations that include adults in high-income countries was conducted. Meta-analysis was performed for descriptive purposes.RESULTS:
During the studied time interval, the estimated incidence rate of E. coli bacteremia was 48 per 100 000 person-years, but this increased considerably with age rates per 100â 000 person-years wereâ >100 in 55-to-75-year-olds andâ >300 in 75-to-85-year-olds. Overall, E. coli accounted for 27% of documented bacteremia episodes 18% if hospital acquired, 32% if community-onset healthcare associated, and 33% if community acquired. The estimated case fatality rate was 12%. Approximately 44% of episodes were community acquired, 27% community-onset healthcare associated, and 27% hospital acquired. Urinary tract infection (UTI) was the primary source for 53% of episodes.CONCLUSIONS:
This systematic review confirms the substantial burden of E. coli bacteremia in older adults and justifies the implementation of community-level programs to prevent E. coli bacteremia and ideally UTI in this age group.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções Urinárias
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Bacteriemia
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Infecções Comunitárias Adquiridas
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Infecções por Escherichia coli
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article