Luteolin prevents liver from tunicamycin-induced endoplasmic reticulum stress via nuclear factor erythroid 2-related factor 2-dependent sestrin 2 induction.

Jegal, Kyung Hwan; Kim, Eun Ok; Kim, Jae Kwang; Park, Sang Mi; Jung, Dae Hwa; Lee, Gum Hwa; Ki, Sung Hwan; Byun, Sung Hui; Ku, Sae Kwang; Cho, Il Je; Kim, Sang Chan

Jegal, Kyung Hwan; Kim, Eun Ok; Kim, Jae Kwang; Park, Sang Mi; Jung, Dae Hwa; Lee, Gum Hwa; Ki, Sung Hwan; Byun, Sung Hui; Ku, Sae Kwang; Cho, Il Je; Kim, Sang Chan.

Afiliação

Jegal KH; College of Korean Medicine, Daegu Haany University, Gyeongsan, Gyeongsangbuk-do 38610, Republic of Korea; College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
Kim EO; College of Korean Medicine, Daegu Haany University, Gyeongsan, Gyeongsangbuk-do 38610, Republic of Korea.
Kim JK; College of Korean Medicine, Daegu Haany University, Gyeongsan, Gyeongsangbuk-do 38610, Republic of Korea.
Park SM; College of Korean Medicine, Daegu Haany University, Gyeongsan, Gyeongsangbuk-do 38610, Republic of Korea.
Jung DH; Hani Bio Co., Ltd, 142 Yulam-ro, Daegu 41059, Republic of Korea.
Lee GH; College of Pharmacy, Chosun University, Gwangju 61452, Republic of Korea.
Ki SH; College of Pharmacy, Chosun University, Gwangju 61452, Republic of Korea.
Byun SH; College of Korean Medicine, Daegu Haany University, Gyeongsan, Gyeongsangbuk-do 38610, Republic of Korea.
Ku SK; College of Korean Medicine, Daegu Haany University, Gyeongsan, Gyeongsangbuk-do 38610, Republic of Korea.
Cho IJ; College of Korean Medicine, Daegu Haany University, Gyeongsan, Gyeongsangbuk-do 38610, Republic of Korea. Electronic address: skek023@dhu.ac.kr.
Kim SC; College of Korean Medicine, Daegu Haany University, Gyeongsan, Gyeongsangbuk-do 38610, Republic of Korea. Electronic address: sckim@dhu.ac.kr.

Toxicol Appl Pharmacol ; 399: 115036, 2020 07 15.

Article em En | MEDLINE | ID: mdl-32407927

Assuntos

Estresse do Retículo Endoplasmático/efeitos dos fármacos; Fígado/efeitos dos fármacos; Luteolina/farmacologia; Fator 2 Relacionado a NF-E2/metabolismo; Proteínas Nucleares/metabolismo; Tunicamicina/farmacologia; Animais; Elementos de Resposta Antioxidante/efeitos dos fármacos; Apoptose/efeitos dos fármacos; Linhagem Celular; Linhagem Celular Tumoral; Células HEK293; Células Hep G2; Hepatócitos/efeitos dos fármacos; Hepatócitos/metabolismo; Humanos; Fígado/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos ICR; Fosforilação/efeitos dos fármacos; Fator de Transcrição CHOP/metabolismo; Resposta a Proteínas não Dobradas/efeitos dos fármacos

Palavras-chave

Endoplasmic reticulum (ER) stress; Liver; Luteolin; Nuclear factor erythroid 2-related factor 2 (Nrf2); Sestrin 2 (SESN2)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Nucleares / Tunicamicina / Luteolina / Fator 2 Relacionado a NF-E2 / Estresse do Retículo Endoplasmático / Fígado Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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