Gelatin-crosslinked pectin nanofiber mats allowing cell infiltration.
Mater Sci Eng C Mater Biol Appl
; 112: 110941, 2020 Jul.
Article
em En
| MEDLINE
| ID: mdl-32409087
ABSTRACT
Pectin nanofiber mats are promising tissue engineering scaffolds but suffer from poor cell infiltration. In this study, gelatin, a collagen derived cell adhesive protein, was used to crosslink the electrospun nanofibers of periodate oxidized pectin. Cell culture experiment results demonstrated that cells were able to grow into the gelatin-crosslinked pectin nanofiber mats rather than only spread on mat surface. The nanofiber mats showed moderate mechanical strength, with a maximum tensile strength of up to 2.3 MPa, an ultimate tensile strain of up to 15%, and were capable of degrading gradually over 4 weeks or even longer periods in simulated body fluids. Thus, gelatin-crosslinked pectin nanofiber mats hold a great potential for soft tissue regeneration.
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Base de dados:
MEDLINE
Assunto principal:
Materiais Biocompatíveis
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Pectinas
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Nanofibras
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article