Nutrients and Porphyria: An Intriguing Crosstalk.
Int J Mol Sci
; 21(10)2020 May 14.
Article
em En
| MEDLINE
| ID: mdl-32422947
ABSTRACT
Porphyria refers to a group of fascinating diseases from a metabolic and nutritional standpoint as it provides an example of how metabolic manipulation can be used for therapeutic purposes. It is characterized by defects in heme synthesis, particularly in the erythrocytes and liver. Specific enzymes involved in heme biosynthesis directly depend on adequate levels of vitamins and minerals in the tissues. Moreover, micronutrients that are required for producing succinyl CoA and other intermediates in the Krebs (TCA) cycle are indirectly necessary for heme metabolism. This review summarizes articles that describe the nutritional status, supplements intake, and dietary practices of patients affected by porphyria, paying special attention to the therapeutic use of nutrients that may help or hinder this group of diseases.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Porfirias
/
Nutrientes
/
Estado Nutricional
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article