CX3CR1-Targeted PLGA Nanoparticles Reduce Microglia Activation and Pain Behavior in Rats with Spinal Nerve Ligation.

Noh, Chan; Shin, Hyo Jung; Lee, Seounghun; Kim, Song I; Kim, Yoon-Hee; Lee, Won Hyung; Kim, Dong Woon; Lee, Sun Yeul; Ko, Young Kwon

Noh, Chan; Shin, Hyo Jung; Lee, Seounghun; Kim, Song I; Kim, Yoon-Hee; Lee, Won Hyung; Kim, Dong Woon; Lee, Sun Yeul; Ko, Young Kwon.

Afiliação

Noh C; Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital, 282 Munhwa-ro, Jung-gu, Daejeon 35015, Korea.
Shin HJ; Department of Medical Science, 3 Department of Anatomy and Cell Biology, 4 Brain Research Institute, School of medicine, Chungnam National University, Daejeon 35015, Korea.
Lee S; Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital, 282 Munhwa-ro, Jung-gu, Daejeon 35015, Korea.
Kim SI; Department of Medical Science, 3 Department of Anatomy and Cell Biology, 4 Brain Research Institute, School of medicine, Chungnam National University, Daejeon 35015, Korea.
Kim YH; Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital, 282 Munhwa-ro, Jung-gu, Daejeon 35015, Korea.
Lee WH; Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital, 282 Munhwa-ro, Jung-gu, Daejeon 35015, Korea.
Kim DW; Department of Medical Science, 3 Department of Anatomy and Cell Biology, 4 Brain Research Institute, School of medicine, Chungnam National University, Daejeon 35015, Korea.
Lee SY; Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital, 282 Munhwa-ro, Jung-gu, Daejeon 35015, Korea.
Ko YK; Department of Anesthesiology and Pain Medicine, Chungnam National University Hospital, 282 Munhwa-ro, Jung-gu, Daejeon 35015, Korea.

Int J Mol Sci ; 21(10)2020 May 14.

Article em En | MEDLINE | ID: mdl-32423102

Assuntos

Receptor 1 de Quimiocina CX3C/genética; Nanopartículas/química; Neuralgia/tratamento farmacológico; RNA Interferente Pequeno/farmacologia; Nervos Espinhais/efeitos dos fármacos; Animais; Comportamento Animal/efeitos dos fármacos; Receptor 1 de Quimiocina CX3C/antagonistas & inibidores; Humanos; Ligadura; Lipopolissacarídeos/farmacologia; Ativação de Macrófagos/efeitos dos fármacos; Microglia/efeitos dos fármacos; Neuralgia/genética; Neuralgia/patologia; Manejo da Dor; Medição da Dor/métodos; Copolímero de Ácido Poliláctico e Ácido Poliglicólico/química; Copolímero de Ácido Poliláctico e Ácido Poliglicólico/farmacologia; RNA Interferente Pequeno/genética; Ratos; Medula Espinal/efeitos dos fármacos; Medula Espinal/patologia; Corno Dorsal da Medula Espinal/efeitos dos fármacos; Corno Dorsal da Medula Espinal/patologia; Nervos Espinhais/metabolismo; Nervos Espinhais/patologia

Palavras-chave

CX3CR1; Poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles; microglia; neuropathic pain; siRNA; spinal nerve ligation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nervos Espinhais / RNA Interferente Pequeno / Nanopartículas / Receptor 1 de Quimiocina CX3C / Neuralgia Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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