Migraine, Human Genetics and a Passion for Science.
Twin Res Hum Genet
; 23(2): 105-106, 2020 04.
Article
em En
| MEDLINE
| ID: mdl-32423498
ABSTRACT
This note reflects on my collaborations with Nick Martin and the GenEpi group over the past 20 years. Over the past two decades, our work together has focused on gene mapping and understanding the genetic architecture of a wide range of traits with particular foci on migraine and common baldness. Our migraine research has included latent class and twin analyses cumulating in genome-wide association analyses which had identified 44 (34 new) risk variants for migraine. Leveraging these results through polygenic risk score analyses identified subgroups of patients likely to respond to triptans (an acute migraine drug), providing the first step toward precision medicine in migraine [Kogelman et al. (2019) Neurology Genetics, 5, e364].
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MEDLINE
Assunto principal:
Predisposição Genética para Doença
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Transtornos de Enxaqueca
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article