Large-scale electron microscopy database for human type 1 diabetes.
Nat Commun
; 11(1): 2475, 2020 05 18.
Article
em En
| MEDLINE
| ID: mdl-32424134
ABSTRACT
Autoimmune ß-cell destruction leads to type 1 diabetes, but the pathophysiological mechanisms remain unclear. To help address this void, we created an open-access online repository, unprecedented in its size, composed of large-scale electron microscopy images ('nanotomy') of human pancreas tissue obtained from the Network for Pancreatic Organ donors with Diabetes (nPOD; www.nanotomy.org). Nanotomy allows analyses of complete donor islets with up to macromolecular resolution. Anomalies we found in type 1 diabetes included (i) an increase of 'intermediate cells' containing granules resembling those of exocrine zymogen and endocrine hormone secreting cells; and (ii) elevated presence of innate immune cells. These are our first results of mining the database and support recent findings that suggest that type 1 diabetes includes abnormalities in the exocrine pancreas that may induce endocrine cellular stress as a trigger for autoimmunity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Microscopia Eletrônica
/
Ilhotas Pancreáticas
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Bases de Dados como Assunto
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Diabetes Mellitus Tipo 1
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article