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Drug repurposing of pyrimidine analogs as potent antiviral compounds against human enterovirus A71 infection with potential clinical applications.
Sun, Jialei; Yogarajah, Thinesshwary; Lee, Regina Ching Hua; Kaur, Parveen; Inoue, Masafumi; Tan, Yong Wah; Chu, Justin Jang Hann.
Afiliação
  • Sun J; Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, MD4 Level 5, 5 Science Drive 2, Singapore, 117597, Singapore.
  • Yogarajah T; Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, MD4 Level 5, 5 Science Drive 2, Singapore, 117597, Singapore.
  • Lee RCH; Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, MD4 Level 5, 5 Science Drive 2, Singapore, 117597, Singapore.
  • Kaur P; Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, MD4 Level 5, 5 Science Drive 2, Singapore, 117597, Singapore.
  • Inoue M; Experimental Therapeutics Centre, Agency for Science, Technology and Research, Singapore, Singapore.
  • Tan YW; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos #06-05, 138673, Singapore, Singapore.
  • Chu JJH; Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, MD4 Level 5, 5 Science Drive 2, Singapore, 117597, Singapore. miccjh@nus.edu.sg.
Sci Rep ; 10(1): 8159, 2020 05 18.
Article em En | MEDLINE | ID: mdl-32424333
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Pirimidinas / Enterovirus Humano A / Desoxicitidina / Infecções por Enterovirus Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Antivirais / Pirimidinas / Enterovirus Humano A / Desoxicitidina / Infecções por Enterovirus Idioma: En Ano de publicação: 2020 Tipo de documento: Article