Pak1 maintains epidermal stem cells by regulating Langerhans cells and is required for skin carcinogenesis.

Okumura, Kazuhiro; Saito, Megumi; Yoshizawa, Yasuhiro; Ito, Yuki; Isogai, Eriko; Araki, Kimi; Wakabayashi, Yuichi

Okumura, Kazuhiro; Saito, Megumi; Yoshizawa, Yasuhiro; Ito, Yuki; Isogai, Eriko; Araki, Kimi; Wakabayashi, Yuichi.

Afiliação

Okumura K; Department of Carcinogenesis Research, Division of Experimental Animal Research, Chiba Cancer Center Research Institute, 666-2 Nitonacho Chuo-ku, Chiba, 260-8717, Japan.
Saito M; Department of Carcinogenesis Research, Division of Experimental Animal Research, Chiba Cancer Center Research Institute, 666-2 Nitonacho Chuo-ku, Chiba, 260-8717, Japan.
Yoshizawa Y; Department of Carcinogenesis Research, Division of Experimental Animal Research, Chiba Cancer Center Research Institute, 666-2 Nitonacho Chuo-ku, Chiba, 260-8717, Japan.
Ito Y; Department of Carcinogenesis Research, Division of Experimental Animal Research, Chiba Cancer Center Research Institute, 666-2 Nitonacho Chuo-ku, Chiba, 260-8717, Japan.
Isogai E; Department of Carcinogenesis Research, Division of Experimental Animal Research, Chiba Cancer Center Research Institute, 666-2 Nitonacho Chuo-ku, Chiba, 260-8717, Japan.
Araki K; Division of Developmental Genetics, Institute of Resource Development and Analysis, 2-2-1 Honjo Chuo-ku, Kumamoto, 860-0811, Japan.
Wakabayashi Y; Department of Carcinogenesis Research, Division of Experimental Animal Research, Chiba Cancer Center Research Institute, 666-2 Nitonacho Chuo-ku, Chiba, 260-8717, Japan. yuichi_wakabayashi@chiba-cc.jp.

Oncogene ; 39(24): 4756-4769, 2020 06.

Article em En | MEDLINE | ID: mdl-32427988

Assuntos

Carcinogênese/metabolismo; Epiderme/metabolismo; Células de Langerhans/metabolismo; Proteínas de Neoplasias/metabolismo; Neoplasias Cutâneas/metabolismo; Células-Tronco/metabolismo; Quinases Ativadas por p21/metabolismo; Animais; Carcinogênese/genética; Carcinogênese/patologia; Epiderme/patologia; Células de Langerhans/patologia; Camundongos; Camundongos Knockout; Proteínas de Neoplasias/genética; Neoplasias Cutâneas/genética; Neoplasias Cutâneas/patologia; Células-Tronco/patologia; Quinases Ativadas por p21/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Células-Tronco / Células de Langerhans / Epiderme / Quinases Ativadas por p21 / Carcinogênese / Proteínas de Neoplasias Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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