HLTF Promotes Fork Reversal, Limiting Replication Stress Resistance and Preventing Multiple Mechanisms of Unrestrained DNA Synthesis.

Bai, Gongshi; Kermi, Chames; Stoy, Henriette; Schiltz, Carl J; Bacal, Julien; Zaino, Angela M; Hadden, M Kyle; Eichman, Brandt F; Lopes, Massimo; Cimprich, Karlene A

Bai, Gongshi; Kermi, Chames; Stoy, Henriette; Schiltz, Carl J; Bacal, Julien; Zaino, Angela M; Hadden, M Kyle; Eichman, Brandt F; Lopes, Massimo; Cimprich, Karlene A.

Afiliação

Bai G; Department of Chemical and Systems Biology, Stanford University School of Medicine, 318 Campus Drive, Stanford, CA 94305-5441, USA.
Kermi C; Department of Chemical and Systems Biology, Stanford University School of Medicine, 318 Campus Drive, Stanford, CA 94305-5441, USA.
Stoy H; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland.
Schiltz CJ; Department of Biological Sciences and Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA.
Bacal J; Department of Chemical and Systems Biology, Stanford University School of Medicine, 318 Campus Drive, Stanford, CA 94305-5441, USA.
Zaino AM; Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Road, Storrs, CT 06029-3092, USA.
Hadden MK; Department of Pharmaceutical Sciences, University of Connecticut, 69 North Eagleville Road, Storrs, CT 06029-3092, USA.
Eichman BF; Department of Biological Sciences and Center for Structural Biology, Vanderbilt University, Nashville, TN 37232, USA.
Lopes M; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland.
Cimprich KA; Department of Chemical and Systems Biology, Stanford University School of Medicine, 318 Campus Drive, Stanford, CA 94305-5441, USA. Electronic address: cimprich@stanford.edu.

Mol Cell ; 78(6): 1237-1251.e7, 2020 06 18.

Article em En | MEDLINE | ID: mdl-32442397

Assuntos

Replicação do DNA/fisiologia; Proteínas de Ligação a DNA/metabolismo; DNA/biossíntese; Fatores de Transcrição/metabolismo; Linhagem Celular Tumoral; DNA/genética; Dano ao DNA/genética; DNA Primase/metabolismo; DNA Primase/fisiologia; Reparo do DNA/genética; Replicação do DNA/genética; Proteínas de Ligação a DNA/genética; DNA Polimerase Dirigida por DNA/metabolismo; DNA Polimerase Dirigida por DNA/fisiologia; Células HEK293; Humanos; Células K562; Enzimas Multifuncionais/metabolismo; Enzimas Multifuncionais/fisiologia; Nucleotidiltransferases/metabolismo; Nucleotidiltransferases/fisiologia; Fatores de Transcrição/genética

Palavras-chave

DNA replication, replication stress response, fork reversal, HLTF, PRIMPOL, REV1, DNA damage tolerance, translesion synthesis, ATR inhibition, replication catastrophe

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / DNA / Proteínas de Ligação a DNA / Replicação do DNA Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google