Activated Cardiac Fibroblasts Control Contraction of Human Fibrotic Cardiac Microtissues by a ß-Adrenoreceptor-Dependent Mechanism.

Blyszczuk, Przemyslaw; Zuppinger, Christian; Costa, Ana; Nurzynska, Daria; Di Meglio, Franca Di; Stellato, Mara; Agarkova, Irina; Smith, Godfrey L; Distler, Oliver; Kania, Gabriela

Blyszczuk, Przemyslaw; Zuppinger, Christian; Costa, Ana; Nurzynska, Daria; Di Meglio, Franca Di; Stellato, Mara; Agarkova, Irina; Smith, Godfrey L; Distler, Oliver; Kania, Gabriela.

Afiliação

Blyszczuk P; Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Wagistr. 14, 8952 Schlieren, Switzerland.
Zuppinger C; Department of Clinical Immunology, Jagiellonian University Medical College, 30-663 Cracow, Poland.
Costa A; Department for BioMedical Research, Department of Cardiology, University Hospital Bern, 3008 Bern,Switzerland.
Nurzynska D; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK.
Di Meglio FD; Department of Public Health, University of Naples "Federico II", 80131 Naples, Italy.
Stellato M; Department of Public Health, University of Naples "Federico II", 80131 Naples, Italy.
Agarkova I; Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Wagistr. 14, 8952 Schlieren, Switzerland.
Smith GL; InSphero, 8952 Schlieren, Switzerland.
Distler O; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK.
Kania G; Center of Experimental Rheumatology, Department of Rheumatology, University Hospital Zurich, Wagistr. 14, 8952 Schlieren, Switzerland.

Cells ; 9(5)2020 05 20.

Article em En | MEDLINE | ID: mdl-32443848

Assuntos

Fibroblastos/metabolismo; Fibroblastos/patologia; Miocárdio/patologia; Receptores Adrenérgicos beta/metabolismo; Engenharia Tecidual; Adulto; Fenômenos Eletrofisiológicos/efeitos dos fármacos; Feto/patologia; Fibroblastos/efeitos dos fármacos; Fibrose; Frequência Cardíaca/efeitos dos fármacos; Humanos; Células-Tronco Pluripotentes Induzidas/citologia; Células-Tronco Pluripotentes Induzidas/efeitos dos fármacos; Fenótipo; Transdução de Sinais/efeitos dos fármacos; Fator de Crescimento Transformador beta1/farmacologia

Palavras-chave

TGF-ß signalling; cardiac fibroblasts; cardiac fibrosis; cardiac microtissues; cardiac rhythm; drug screening; iPSC-derived cardiomyocytes; in vitro model

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Adrenérgicos beta / Engenharia Tecidual / Fibroblastos / Miocárdio Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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