Population pharmacokinetic/pharmacodynamic modelling of nifekalant in healthy Chinese volunteers.

Zhang, Jiashan; Zan, Ying; Huo, Hua; Liu, Yanfang; Tang, Yunbiao; Han, Yaling

Zhang, Jiashan; Zan, Ying; Huo, Hua; Liu, Yanfang; Tang, Yunbiao; Han, Yaling.

Afiliação

Zhang J; Department of Phase I Clinical Trial Unit, General Hospital of Northern Theater Command; Department of Clinical Pharmacy, School of Life Science and Biopharmaceutical Institute, Shenyang Pharmaceutical University, Shenyang, China.
Zan Y; Clinical Trial Institution Office, PKUCare Luzhong Hospital, Zibo, China.
Huo H; Department of Phase I Clinical Trial Unit, General Hospital of Northern Theater Command.
Liu Y; Department of Phase I Clinical Trial Unit, General Hospital of Northern Theater Command.
Tang Y; Department of Phase I Clinical Trial Unit, General Hospital of Northern Theater Command. Electronic address: tangyb99@163.com.
Han Y; Cardiovascular Research Institute and Department of Cardiology, General Hospital of Northern Theater Command. Electronic address: hanyaling01@163.com.

Eur J Pharm Sci ; 151: 105385, 2020 Aug 01.

Article em En | MEDLINE | ID: mdl-32454129

Assuntos

Modelos Biológicos; Espectrometria de Massas em Tandem; China; Cromatografia Líquida; Relação Dose-Resposta a Droga; Voluntários Saudáveis; Humanos; Pirimidinonas

Palavras-chave

Nifekalant; PK/PD; QT interval

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Espectrometria de Massas em Tandem / Modelos Biológicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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