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Regioselective synthesis and anticancer evaluation of H2O2-activable nucleosides.
Sun, Ying-Jie; Liu, Li; Cheng, Liang.
Afiliação
  • Sun YJ; Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. chengl@iccas.ac.cn and University of Chinese Academy of Sciences, Beijing 100049, China.
  • Liu L; Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. chengl@iccas.ac.cn and University of Chinese Academy of Sciences, Beijing 100049, China.
  • Cheng L; Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China. chengl@iccas.ac.cn and University of Chinese Academy of Sciences, Beijing 100049, China.
Chem Commun (Camb) ; 56(48): 6484-6487, 2020 Jun 16.
Article em En | MEDLINE | ID: mdl-32458844
ABSTRACT
We describe here the design, synthesis, and biological evaluation of H2O2-activatable nucleosides via an efficient and regioselective functionalization of unprotected precursors. Biological evaluation of a H2O2-specific responsive prodrug of gemecitabin demonstrates an extremely fast activation, low toxicity and enhanced anticancer effects in two cell lines.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peróxido de Hidrogênio / Antineoplásicos / Nucleosídeos Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peróxido de Hidrogênio / Antineoplásicos / Nucleosídeos Idioma: En Ano de publicação: 2020 Tipo de documento: Article