Regioselective synthesis and anticancer evaluation of H2O2-activable nucleosides.
Chem Commun (Camb)
; 56(48): 6484-6487, 2020 Jun 16.
Article
em En
| MEDLINE
| ID: mdl-32458844
ABSTRACT
We describe here the design, synthesis, and biological evaluation of H2O2-activatable nucleosides via an efficient and regioselective functionalization of unprotected precursors. Biological evaluation of a H2O2-specific responsive prodrug of gemecitabin demonstrates an extremely fast activation, low toxicity and enhanced anticancer effects in two cell lines.
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1
Base de dados:
MEDLINE
Assunto principal:
Peróxido de Hidrogênio
/
Antineoplásicos
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Nucleosídeos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article