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Pd-Catalyzed Dearomative Asymmetric Allylic Alkylation of Naphthols with Alkoxyallenes.
Hu, Jinjin; Pan, Shulei; Zhu, Shuai; Yu, Peiyuan; Xu, Ruigang; Zhong, Guofu; Zeng, Xiaofei.
Afiliação
  • Hu J; College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China.
  • Pan S; College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China.
  • Zhu S; Shenzhen Grubbs Institute and Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, China.
  • Yu P; Shenzhen Grubbs Institute and Department of Chemistry, Southern University of Science and Technology, Shenzhen 518055, China.
  • Xu R; College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China.
  • Zhong G; College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China.
  • Zeng X; College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China.
J Org Chem ; 85(12): 7896-7904, 2020 Jun 19.
Article em En | MEDLINE | ID: mdl-32466648
ABSTRACT
A Pd-catalyzed linear selective intermolecular asymmetric dearomative allylic alkylation reaction of naphthols with alkoxyallenes under mild reaction conditions is reported. The transformation is successfully promoted by Pd2(dba)3 and the chiral Trost ligand and provides a general atom-efficient protocol to obtain various ß-naphthalenones bearing an all carbon quaternary stereogenic center in good yields and chemo- and stereoselectivities.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article