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Discovery of ORN0829, a potent dual orexin 1/2 receptor antagonist for the treatment of insomnia.
Futamura, Aya; Suzuki, Ryo; Tamura, Yunoshin; Kawamoto, Hiroshi; Ohmichi, Mari; Hino, Noriko; Tokumaru, Yuichi; Kirinuki, Sora; Hiyoshi, Tetsuaki; Aoki, Takeshi; Kambe, Daiji; Nozawa, Dai.
Afiliação
  • Futamura A; Discovery Research Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
  • Suzuki R; Discovery Research Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
  • Tamura Y; Discovery Research Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
  • Kawamoto H; Discovery Research Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
  • Ohmichi M; Drug Safety and Pharmacokinetics Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
  • Hino N; Discovery Research Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
  • Tokumaru Y; Discovery Research Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
  • Kirinuki S; Discovery Research Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
  • Hiyoshi T; Discovery Research Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
  • Aoki T; Discovery Research Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
  • Kambe D; Discovery Research Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan.
  • Nozawa D; Discovery Research Laboratories, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama 331-9530, Japan. Electronic address: d-nozawa@taisho.co.jp.
Bioorg Med Chem ; 28(13): 115489, 2020 07 01.
Article em En | MEDLINE | ID: mdl-32482533
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Orexina / Orexinas / Antagonistas dos Receptores de Orexina / Distúrbios do Início e da Manutenção do Sono Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Orexina / Orexinas / Antagonistas dos Receptores de Orexina / Distúrbios do Início e da Manutenção do Sono Idioma: En Ano de publicação: 2020 Tipo de documento: Article