Complement Evasion by Lyme Disease Spirochetes.
Trends Microbiol
; 28(11): 889-899, 2020 11.
Article
em En
| MEDLINE
| ID: mdl-32482556
ABSTRACT
The complement system is an ancient arm of the innate immune system that plays important roles in pathogen recognition and elimination. Upon activation by microbes, complement opsonizes bacterial surfaces, recruits professional phagocytes, and causes bacteriolysis. Borreliella species are spirochetal bacteria that are transmitted to vertebrate hosts via infected Ixodes ticks and are the etiologic agents of Lyme disease. Pathogens that traffic in blood and other body fluids, like Borreliella, have evolved means to evade complement. Lyme disease spirochetes interfere with complement by producing a small arsenal of outer-surface lipoproteins that bind host complement components and manipulate their native activities. Here we review the current landscape of complement evasion by Lyme disease spirochetes and provide an update on recent discoveries.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas do Sistema Complemento
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Doença de Lyme
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Borrelia burgdorferi
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Evasão da Resposta Imune
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article