Destabilization of light NREM sleep by thalamic PLCß4 deletion impairs sleep-dependent memory consolidation.
Sci Rep
; 10(1): 8813, 2020 06 01.
Article
em En
| MEDLINE
| ID: mdl-32483199
ABSTRACT
Sleep abnormality often accompanies the impairment of cognitive function. Both rapid eye movement (REM) and non-REM (NREM) sleep have associated with improved memory performance. However, the role of composition in NREM sleep, consisting of light and deep NREM, for memory formation is not fully understood. We investigated how the dynamics of NREM sleep states influence memory consolidation. Thalamocortical (TC) neuron-specific phospholipase C ß4 (PLCß4) knockout (KO) increased the total duration of NREM sleep, consisting of destabilized light NREM and stabilized deep NREM. Surprisingly, the longer NREM sleep did not improve memory consolidation but rather impaired it in TC-specific PLCß4 KO mice. Memory function was positively correlated with the stability of light NREM and spindle activity occurring in maintained light NREM period. Our study suggests that a single molecule, PLCß4, in TC neurons is critical for tuning the NREM sleep states and thus affects sleep-dependent memory formation.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Fases do Sono
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Tálamo
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Fosfolipase C beta
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Consolidação da Memória
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Transtornos da Memória
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Proteínas do Tecido Nervoso
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article