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Glycyrrhetinic Acid Liposomes and Hyalurosomes on Spanish Broom, Flax, and Hemp Dressings to Heal Skin Wounds.
Abruzzo, Angela; Cappadone, Concettina; Farruggia, Giovanna; Luppi, Barbara; Bigucci, Federica; Cerchiara, Teresa.
Afiliação
  • Abruzzo A; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via San Donato 19/2, 40127 Bologna, Italy.
  • Cappadone C; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via San Donato 19/2, 40127 Bologna, Italy.
  • Farruggia G; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via San Donato 19/2, 40127 Bologna, Italy.
  • Luppi B; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via San Donato 19/2, 40127 Bologna, Italy.
  • Bigucci F; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via San Donato 19/2, 40127 Bologna, Italy.
  • Cerchiara T; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, Via San Donato 19/2, 40127 Bologna, Italy.
Molecules ; 25(11)2020 May 31.
Article em En | MEDLINE | ID: mdl-32486398
ABSTRACT
The focus of this work was to prepare Spanish Broom, flax, and hemp dressings impregnated with glycyrrhetinic acid (GA) liposomes or hyalurosomes to promote the healing process and protect the skin wounds. Vesicles were prepared by the film hydration method and characterized in terms of size, particle size distribution, ζ potential, encapsulation efficiency, in vitro release, and biocompatibility on 3T3 fibroblasts. Loaded liposomes and hyalurosomes showed nanometric size (355 ± 19 nm and 424 ± 32 nm, respectively), good size distribution (lower than 0.3), and appropriate encapsulation efficiency (58.62 ± 3.25% and 59.22 ± 8.18%, respectively). Hyalurosomes showed good stability during the storage period, which can be correlated to the negative ζ potential, and allowed a fast and complete release of GA. Preliminary biological studies revealed that both kinds of loaded vesicles were not cytotoxic and that hyalurosomes could exert a slight stimulating effect on fibroblast proliferation. Finally, in vitro release studies from the different dressings impregnated with the loaded vesicles demonstrated that a high amount of GA could be reached at the wound site after 60 min from application. In conclusion, the results suggested that the developed dressings, especially those impregnated with hyalurosomes, can be efficiently used to promote the healing process.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cicatrização / Cannabis / Linho / Spartium / Ácido Glicirretínico / Ácido Hialurônico / Lipossomos Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cicatrização / Cannabis / Linho / Spartium / Ácido Glicirretínico / Ácido Hialurônico / Lipossomos Idioma: En Ano de publicação: 2020 Tipo de documento: Article