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An up-to-date overview of sublingual sufentanil for the treatment of moderate to severe pain.
Porela-Tiihonen, Susanna; Kokki, Hannu; Kokki, Merja.
Afiliação
  • Porela-Tiihonen S; Department of Anaesthesia and Operative Services, Kuopio University Hospital , Kuopio, Finland.
  • Kokki H; Department of Anaesthesia and Operative Services, Kuopio University Hospital , Kuopio, Finland.
  • Kokki M; Department of Anaesthesia and Operative Services, Kuopio University Hospital , Kuopio, Finland.
Expert Opin Pharmacother ; 21(12): 1407-1418, 2020 Aug.
Article em En | MEDLINE | ID: mdl-32486875
ABSTRACT

INTRODUCTION:

Sufentanil is a selective µ-opioid agonist, used intravenously and intrathecally for moderate to severe acute pain. Sublingual sufentanil nanotablets have been developed; 15 mcg tablet for a patient-controlled analgesia device and 30-mcg tablet for a single-dose device administered by a healthcare professional. Dosing interval is a minimum of 20 min for a 15 mcg tablet and a treatment duration of up to 72 hours. The single 30-mcg nanotablet dosing interval is 1 hour. Mean plasma elimination half-life is 13 hours and bioavailability 47-57% after the first sublingual sufentanil tablet. AREAS COVERED This review focuses on the effectiveness, safety, and feasibility of sublingual sufentanil 30-mcg single dose suspended by a healthcare professional for the management of moderate to severe acute pain. A few Phase 4 studies concerning the sublingual sufentanil tablet system containing 15-mcg nanotablets are also reviewed. EXPERT OPINION Sufentanil sublingual 30-mcg nanotablets provide effective pain relief in various acute moderate to severe pain states. The safety profile of sublingual sufentanil 30 mcg is typical to opioids nausea, vomiting, and sedation being the most common ones. Sublingual sufentanil 30-mcg nanotablet has the potential for efficient moderate to severe pain management in supervised healthcare facilities.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dor Pós-Operatória / Sistemas de Liberação de Medicamentos / Sufentanil / Dor Aguda / Manejo da Dor / Analgésicos Opioides Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dor Pós-Operatória / Sistemas de Liberação de Medicamentos / Sufentanil / Dor Aguda / Manejo da Dor / Analgésicos Opioides Idioma: En Ano de publicação: 2020 Tipo de documento: Article