Thermal Adaptation of Enzymes: Impacts of Conformational Shifts on Catalytic Activation Energy and Optimum Temperature.

Maffucci, Irene; Laage, Damien; Sterpone, Fabio; Stirnemann, Guillaume

Maffucci, Irene; Laage, Damien; Sterpone, Fabio; Stirnemann, Guillaume.

Afiliação

Maffucci I; PASTEUR, Département de chimie, École Normale Supérieure, PSL University, Sorbonne Université, CNRS, 24 rue Lhomond, 75005, Paris, France.
Laage D; CNRS Laboratoire de Biochimie Théorique, Institut de Biologie Physico-Chimique, PSL University, Université de Paris, 13 rue Pierre et Marie Curie, 75005, Paris, France.
Sterpone F; Present address: Centre de recherche Royallieu, Université de Technologie de Compiègne, UPJV, CNRS, Enzyme and Cell Engineering, CS 60319-60203, Compiègne Cedex, France.
Stirnemann G; PASTEUR, Département de chimie, École Normale Supérieure, PSL University, Sorbonne Université, CNRS, 24 rue Lhomond, 75005, Paris, France.

Chemistry ; 26(44): 10045-10056, 2020 Aug 06.

Article em En | MEDLINE | ID: mdl-32490588

Assuntos

Biocatálise; Enzimas/química; Enzimas/metabolismo; Temperatura; Cinética; Conformação Proteica

Palavras-chave

biophysics; dihydrofolate reductase; enzymes catalysis; optimum activity; thermal adaptation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Temperatura / Enzimas / Biocatálise Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Temperatura / Enzimas / Biocatálise Idioma: En Ano de publicação: 2020 Tipo de documento: Article