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Suramin and NF449 are IP5K inhibitors that disrupt inositol hexakisphosphate-mediated regulation of cullin-RING ligase and sensitize cancer cells to MLN4924/pevonedistat.
Zhang, Xiaozhe; Shi, Shaodong; Su, Yang; Yang, Xiaoli; He, Sining; Yang, Xiuyan; Wu, Jing; Zhang, Jian; Rao, Feng.
Afiliação
  • Zhang X; College of Biological Sciences, China Agricultural University, Beijing, China.
  • Shi S; Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China.
  • Su Y; Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China.
  • Yang X; Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China.
  • He S; Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China.
  • Yang X; Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China.
  • Wu J; Department of Biology, Southern University of Science and Technology, Shenzhen, Guangdong, China.
  • Zhang J; Key Laboratory of Cell Differentiation and Apoptosis, Ministry of Education, Department of Pathophysiology, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
  • Rao F; Key Laboratory of Cell Differentiation and Apoptosis, Ministry of Education, Department of Pathophysiology, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
J Biol Chem ; 295(30): 10281-10292, 2020 07 24.
Article em En | MEDLINE | ID: mdl-32493769
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Fítico / Pirimidinas / Suramina / Benzenossulfonatos / Fosfotransferases (Aceptor do Grupo Álcool) / Ciclopentanos / Proteínas Culina / Inibidores Enzimáticos / Proteínas de Neoplasias / Neoplasias Idioma: En Ano de publicação: 2020 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácido Fítico / Pirimidinas / Suramina / Benzenossulfonatos / Fosfotransferases (Aceptor do Grupo Álcool) / Ciclopentanos / Proteínas Culina / Inibidores Enzimáticos / Proteínas de Neoplasias / Neoplasias Idioma: En Ano de publicação: 2020 Tipo de documento: Article