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Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth.
Lechertier, Tanguy; Reynolds, Louise E; Kim, Hyojin; Pedrosa, Ana Rita; Gómez-Escudero, Jesús; Muñoz-Félix, José M; Batista, Silvia; Dukinfield, Matthew; Demircioglu, Fevzi; Wong, Ping Pui; Matchett, Kylie P; Henderson, Neil C; D'Amico, Gabriela; Parsons, Maddy; Harwood, Catherine; Meier, Pascal; Hodivala-Dilke, Kairbaan M.
Afiliação
  • Lechertier T; Centre for Tumour Biology, Barts Cancer Institute - a CR-UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.
  • Reynolds LE; Centre for Tumour Biology, Barts Cancer Institute - a CR-UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.
  • Kim H; Cell Death & Inflammation, The Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, Fulham Road, London, SW3 6JB, UK.
  • Pedrosa AR; Centre for Tumour Biology, Barts Cancer Institute - a CR-UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.
  • Gómez-Escudero J; Centre for Tumour Biology, Barts Cancer Institute - a CR-UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.
  • Muñoz-Félix JM; Centre for Tumour Biology, Barts Cancer Institute - a CR-UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.
  • Batista S; Systems Oncology Group, Champalimaud Research, Champalimaud Centre for the Unknown Av. Brasília, Doca de Pedrouços, 1400-038, Lisbon, Portugal.
  • Dukinfield M; Centre for Tumour Biology, Barts Cancer Institute - a CR-UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.
  • Demircioglu F; Centre for Tumour Biology, Barts Cancer Institute - a CR-UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.
  • Wong PP; Centre for Tumour Biology, Barts Cancer Institute - a CR-UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.
  • Matchett KP; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 510120, Guangzhou, China.
  • Henderson NC; Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, University of Edinburgh, Edinburgh, UK.
  • D'Amico G; Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, University of Edinburgh, Edinburgh, UK.
  • Parsons M; MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh, UK.
  • Harwood C; Centre for Tumour Biology, Barts Cancer Institute - a CR-UK Centre of Excellence, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, EC1M 6BQ, UK.
  • Meier P; Nikon Imaging Centre@King's, Randall Division of Cell and Molecular Biophysics, Kings College London, Room 3.22B, New Hunts House Guys Campus, London, SE1 1UL, UK.
  • Hodivala-Dilke KM; Centre for Cell Biology and Cutaneous Research, Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AT, UK.
Nat Commun ; 11(1): 2810, 2020 06 04.
Article em En | MEDLINE | ID: mdl-32499572
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação Neoplásica da Expressão Gênica / Proteínas Proto-Oncogênicas / Receptores Proteína Tirosina Quinases / Pericitos / Peptídeos e Proteínas de Sinalização Intercelular / Quinase 1 de Adesão Focal / Proteína Rica em Cisteína 61 / Neovascularização Patológica Idioma: En Ano de publicação: 2020 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Regulação Neoplásica da Expressão Gênica / Proteínas Proto-Oncogênicas / Receptores Proteína Tirosina Quinases / Pericitos / Peptídeos e Proteínas de Sinalização Intercelular / Quinase 1 de Adesão Focal / Proteína Rica em Cisteína 61 / Neovascularização Patológica Idioma: En Ano de publicação: 2020 Tipo de documento: Article