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Alteration in gut microbiota is associated with dysregulation of cytokines and glucocorticoid therapy in systemic lupus erythematosus.
Guo, Mengchen; Wang, Huixia; Xu, Sixie; Zhuang, Yaoyao; An, Jingang; Su, Chuan; Xia, Yankai; Chen, Jingyun; Xu, Zhenjiang Zech; Liu, Qisha; Wang, Jianwei; Dan, Zhou; Chen, Kun; Luan, Xiaoting; Liu, Zhi; Liu, Kangjian; Zhang, Faming; Xia, Yumin; Liu, Xingyin.
Afiliação
  • Guo M; Department of Pathogen Biology-Microbiology Division, State Key Laboratory of Reproductive Medicine, Key Laboratory of Pathogen Biology of Jiangsu Province, Center for Global Health, Nanjing Medical University , Nanjing, China.
  • Wang H; Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University , Nanjing, China.
  • Xu S; Medical Center for Digestive Diseases, the second affiliated Hospital of Nanjing Medical University, Key Laboratory of Holistic integrative Enterology, Nanjing Medical University , Nanjing, China.
  • Zhuang Y; Department of Dermatology, the Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University , Xi'an, China.
  • An J; Department of Pathogen Biology-Microbiology Division, State Key Laboratory of Reproductive Medicine, Key Laboratory of Pathogen Biology of Jiangsu Province, Center for Global Health, Nanjing Medical University , Nanjing, China.
  • Su C; Department of Pathogen Biology-Microbiology Division, State Key Laboratory of Reproductive Medicine, Key Laboratory of Pathogen Biology of Jiangsu Province, Center for Global Health, Nanjing Medical University , Nanjing, China.
  • Xia Y; Department of Dermatology, the Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University , Xi'an, China.
  • Chen J; Department of Pathogen Biology-Microbiology Division, State Key Laboratory of Reproductive Medicine, Key Laboratory of Pathogen Biology of Jiangsu Province, Center for Global Health, Nanjing Medical University , Nanjing, China.
  • Xu ZZ; State Key Laboratory of Reproductive Medicine, Institute of Toxicology , Nanjing, China.
  • Liu Q; Department of Dermatology, the Second Affiliated Hospital, School of Medicine, Xi'an Jiaotong University , Xi'an, China.
  • Wang J; School of Food and Technology State, Key Laboratory of Food Science and Technology, Nanchang University , Nanchang, China.
  • Dan Z; Department of Pathogen Biology-Microbiology Division, State Key Laboratory of Reproductive Medicine, Key Laboratory of Pathogen Biology of Jiangsu Province, Center for Global Health, Nanjing Medical University , Nanjing, China.
  • Chen K; Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University , Nanjing, China.
  • Luan X; Medical Center for Digestive Diseases, the second affiliated Hospital of Nanjing Medical University, Key Laboratory of Holistic integrative Enterology, Nanjing Medical University , Nanjing, China.
  • Liu Z; Department of Pathogen Biology-Microbiology Division, State Key Laboratory of Reproductive Medicine, Key Laboratory of Pathogen Biology of Jiangsu Province, Center for Global Health, Nanjing Medical University , Nanjing, China.
  • Liu K; Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University , Nanjing, China.
  • Zhang F; Medical Center for Digestive Diseases, the second affiliated Hospital of Nanjing Medical University, Key Laboratory of Holistic integrative Enterology, Nanjing Medical University , Nanjing, China.
  • Xia Y; Department of Pathogen Biology-Microbiology Division, State Key Laboratory of Reproductive Medicine, Key Laboratory of Pathogen Biology of Jiangsu Province, Center for Global Health, Nanjing Medical University , Nanjing, China.
  • Liu X; Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University , Nanjing, China.
Gut Microbes ; 11(6): 1758-1773, 2020 11 01.
Article em En | MEDLINE | ID: mdl-32507008
ABSTRACT
A growing corpus of evidence implicates the involvement of the commensal microbiota and immune cytokines in the initiation and progression of systemic lupus erythematosus (SLE). Glucocorticoids have been widely used in the treatment of SLE patients, however, glucocorticoid treatment carries a higher risk of other diseases. Using the 16S rRNA technique, we investigated the differences between the gut microbiota associated with the immune cytokines of SLE and relevant glucocorticoid treatment in a female cohort of 20 healthy control subjects (HC), 17 subjects with SLE (SLE-G), and 20 SLE patients having undergone glucocorticoid treatment (SLE+G). We observed that the diversity and structure of the microbial community in SLE+G patients were significantly changed compared to that of SLE-G patients, whereas the gut microbial community of the SLE+G group showed a similarity with the HC group, which implicate that the shift in the gut microbiome could represent a return to homeostasis. Furthermore, the up-regulations of immune cytokines in SLE-G were identified as closely related to gut dysbiosis, which indicates that the overrepresented genera in SLE patients may play roles in regulating expression level of these immune cytokines. This associated analysis of gut microbiota, glucocorticoid therapy, and immune factors might provide novel and insightful clues revealing the pathogenesis of SLE patients.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Citocinas / Microbioma Gastrointestinal / Glucocorticoides / Lúpus Eritematoso Sistêmico Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Citocinas / Microbioma Gastrointestinal / Glucocorticoides / Lúpus Eritematoso Sistêmico Idioma: En Ano de publicação: 2020 Tipo de documento: Article