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Active targeting nano-scale bubbles enhanced ultrasound cavitation chemotherapy in Y1 receptor-overexpressed breast cancer.
Qian, Xuechen; Wang, Yinjie; Xu, Youfeng; Ma, Ling; Xue, Nianyu; Jiang, Zhenqi; Cao, Yi; Akakuru, Ozioma Udochukwu; Li, Juan; Zhang, Shengmin; Wu, Aiguo.
Afiliação
  • Qian X; Department of Ultrasound, Ningbo First Hospital, Ningbo 315010, China. 1261142692@qq.com.
J Mater Chem B ; 8(31): 6837-6844, 2020 08 21.
Article em En | MEDLINE | ID: mdl-32510101
ABSTRACT
Ultrasound cavitation therapy has attracted much attention in recent years because the cavitation of microbubbles can be leveraged to boost the infiltration of chemotherapeutic drugs into cancer tissues. For breast cancer therapy, most of the previously reported microbubbles lack specific targeting capacity and permeability. In this study, we have successfully fabricated Y1 receptor ligand (NPY)-modified bubbles, and examined their therapeutic efficacies as size-dependent functions with or without NPY targeting. To achieve this, four types of micro-scale bubbles (MBs or MBs-NPY) and nano-scale bubbles (NBs or NBs-NPY) were comprehensively evaluated. In vivo results indicated that the NBs-NPY group with doxorubicin (DOX) under ultrasound irradiation showed a high tumor suppression effect and a prolonged survival time. Furthermore, the NBs-NPY with DOX group exhibited minimal damage to mouse vital organs, which points to the considerable tolerance of the proposed nanosystem for efficacious breast cancer therapy. In summary, these findings suggest that the developed NPY-targeted NBs could have a broad application prospect in ultrasound cavitation chemotherapy of Y1 receptor-overexpressed breast cancer.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Terapia por Ultrassom / Neoplasias da Mama / Regulação Neoplásica da Expressão Gênica / Receptores de Neuropeptídeo Y / Nanomedicina Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Terapia por Ultrassom / Neoplasias da Mama / Regulação Neoplásica da Expressão Gênica / Receptores de Neuropeptídeo Y / Nanomedicina Idioma: En Ano de publicação: 2020 Tipo de documento: Article