Paramagnetic NMR in drug discovery.

Softley, Charlotte A; Bostock, Mark J; Popowicz, Grzegorz M; Sattler, Michael

Softley, Charlotte A; Bostock, Mark J; Popowicz, Grzegorz M; Sattler, Michael.

Afiliação

Softley CA; Biomolecular NMR and Center for Integrated Protein Science Munich at Department Chemie, Technical University of Munich, Lichtenbergstraße 4, 85747, Garching, Germany.
Bostock MJ; Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.
Popowicz GM; Biomolecular NMR and Center for Integrated Protein Science Munich at Department Chemie, Technical University of Munich, Lichtenbergstraße 4, 85747, Garching, Germany.
Sattler M; Institute of Structural Biology, Helmholtz Zentrum München, Ingolstädter Landstraße 1, 85764, Neuherberg, Germany.

J Biomol NMR ; 74(6-7): 287-309, 2020 Jul.

Article em En | MEDLINE | ID: mdl-32524233

Assuntos

Descoberta de Drogas/métodos; Espectroscopia de Ressonância Magnética/métodos; Sítios de Ligação; Ligantes; Proteínas/química; Proteínas/metabolismo; Marcadores de Spin

Palavras-chave

Drug discovery; Fragment screening; Nuclear magnetic resonance; Paramagnetic relaxation enhancement; Paramagnetism; Proteinligand structure determination; Pseudo-contact shift

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Espectroscopia de Ressonância Magnética / Descoberta de Drogas Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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