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Design, synthesis, and pharmacological evaluation of 2-(4-sulfonylphenyl)-2-[(E)-pyrrolidin-1-ylimino]-N-thiazoleacetamides as glucokinase activators.
Sugama, Hiroshi; Matsudaira, Tetsuji; Yanagisawa, Hideyuki; Ohashi, Rikiya; Nawano, Masao; Yasuda, Kosuke; Takayama, Hiromitsu.
Afiliação
  • Sugama H; Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan; Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8675, Japan. Electronic address: sugama.hiroshi@mm.mt-pharma.co.jp.
  • Matsudaira T; Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan.
  • Yanagisawa H; Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan.
  • Ohashi R; Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan.
  • Nawano M; Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan.
  • Yasuda K; Sohyaku, Innovative Research Division, Mitsubishi Tanabe Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama 227-0033, Japan.
  • Takayama H; Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8675, Japan.
Bioorg Med Chem Lett ; 30(15): 127249, 2020 08 01.
Article em En | MEDLINE | ID: mdl-32527453
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiazóis / Diabetes Mellitus Experimental / Diabetes Mellitus Tipo 2 / Glucoquinase / Hipoglicemiantes / Acetamidas Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tiazóis / Diabetes Mellitus Experimental / Diabetes Mellitus Tipo 2 / Glucoquinase / Hipoglicemiantes / Acetamidas Idioma: En Ano de publicação: 2020 Tipo de documento: Article