Salvia miltiorrhiza stems and leaves total phenolic acids combination with tanshinone protect against DSS-induced ulcerative colitis through inhibiting TLR4/PI3K/AKT/mTOR signaling pathway in mice.

Peng, Ke-Yu; Gu, Jun-Fei; Su, Shu-Lan; Zhu, Yue; Guo, Jian-Ming; Qian, Da-Wei; Duan, Jin-Ao

Peng, Ke-Yu; Gu, Jun-Fei; Su, Shu-Lan; Zhu, Yue; Guo, Jian-Ming; Qian, Da-Wei; Duan, Jin-Ao.

Afiliação

Peng KY; Jiangsu Collaborative Innovation Center of Chinese Medicine Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu Province, China. Electronic address: pengkeyu408@163.com.
Gu JF; Basic Medical College, Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu Province, China. Electronic address: gujunfei0123@126.com.
Su SL; Jiangsu Collaborative Innovation Center of Chinese Medicine Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu Province, China. Electronic address: sushulan@njucm.edu.cn.
Zhu Y; Jiangsu Collaborative Innovation Center of Chinese Medicine Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu Province, China. Electronic address: zhuyue@njucm.edu.cn.
Guo JM; Jiangsu Collaborative Innovation Center of Chinese Medicine Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu Province, China. Electronic address: njuguo@njucm.edu.cn.
Qian DW; Jiangsu Collaborative Innovation Center of Chinese Medicine Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu Province, China. Electronic address: qiandwnj@126.com.
Duan JA; Jiangsu Collaborative Innovation Center of Chinese Medicine Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, 210023, Jiangsu Province, China. Electronic address: dja@njucm.edu.cn.

J Ethnopharmacol ; 264: 113052, 2021 Jan 10.

Article em En | MEDLINE | ID: mdl-32535239

Assuntos

Abietanos/administração & dosagem; Colite Ulcerativa/tratamento farmacológico; Hidroxibenzoatos/administração & dosagem; Proteínas Proto-Oncogênicas c-akt/antagonistas & inibidores; Salvia miltiorrhiza; Serina-Treonina Quinases TOR/antagonistas & inibidores; Receptor 4 Toll-Like/antagonistas & inibidores; Animais; Colite Ulcerativa/induzido quimicamente; Colite Ulcerativa/metabolismo; Sulfato de Dextrana/toxicidade; Quimioterapia Combinada; Hidroxibenzoatos/isolamento & purificação; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Fosfatidilinositol 3-Quinases/metabolismo; Inibidores de Fosfoinositídeo-3 Quinase/administração & dosagem; Inibidores de Fosfoinositídeo-3 Quinase/isolamento & purificação; Extratos Vegetais/administração & dosagem; Extratos Vegetais/isolamento & purificação; Folhas de Planta; Caules de Planta; Proteínas Proto-Oncogênicas c-akt/metabolismo; Serina-Treonina Quinases TOR/metabolismo; Receptor 4 Toll-Like/metabolismo

Palavras-chave

Colitis; DSS; Inflammation; Salvia miltiorrhiza; TLR4/PI3K/AKT/mTOR signaling pathway

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Colite Ulcerativa / Salvia miltiorrhiza / Abietanos / Proteínas Proto-Oncogênicas c-akt / Receptor 4 Toll-Like / Serina-Treonina Quinases TOR / Hidroxibenzoatos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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