Thermo-irreversible glycol chitosan/hyaluronic acid blend hydrogel for injectable tissue engineering.
Carbohydr Polym
; 244: 116432, 2020 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-32536405
ABSTRACT
Thermogels that undergo temperature-dependent sol-gel transition have recently attracted attention as a promising biomaterial for injectable tissue engineering. However, conventional thermogels usually suffer from poor physical properties and low cell binding affinity, limiting their practical applications. Here, a simple approach for developing a new thermogel with enhanced physical properties and cell binding affinity is proposed. This thermogel (AcHA/HGC) was obtained by simple blending of a new class of polysaccharide-based thermogel, N-hexanoyl glycol chitosan (HGC), with a polysaccharide possessing good cell binding affinity, acetylated hyaluronic acid (AcHA). Gelation of AcHA/HGC was initially triggered by the thermosensitive response of HGC and gradually intensified by additional physical crosslinking mechanisms between HGC and AcHA, resulting in thermo-irreversible gelation. Compared to the thermos-reversible HGC hydrogel, the thermo-irreversible AcHA/HGC hydrogel exhibited enhanced physical stability, mechanical properties, cell binding affinity, and tissue compatibility. These results suggest that our thermo-irreversible hydrogel is a promising biomaterial for injectable tissue engineering.
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Base de dados:
MEDLINE
Assunto principal:
Materiais Biocompatíveis
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Hidrogéis
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Engenharia Tecidual
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Quitosana
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Ácido Hialurônico
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article