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TEAD-YAP Interaction Inhibitors and MDM2 Binders from DNA-Encoded Indole-Focused Ugi Peptidomimetics.
Kunig, Verena B K; Potowski, Marco; Akbarzadeh, Mohammad; Klika Skopic, Mateja; Dos Santos Smith, Denise; Arendt, Lukas; Dormuth, Ina; Adihou, Hélène; Andlovic, Blaz; Karatas, Hacer; Shaabani, Shabnam; Zarganes-Tzitzikas, Tryfon; Neochoritis, Constantinos G; Zhang, Ran; Groves, Matthew; Guéret, Stéphanie M; Ottmann, Christian; Rahnenführer, Jörg; Fried, Roland; Dömling, Alexander; Brunschweiger, Andreas.
Afiliação
  • Kunig VBK; TU Dortmund University, Faculty of Chemistry and Chemical Biology, Otto-Hahn-Strasse 6, 44227, Dortmund, Germany.
  • Potowski M; TU Dortmund University, Faculty of Chemistry and Chemical Biology, Otto-Hahn-Strasse 6, 44227, Dortmund, Germany.
  • Akbarzadeh M; Max Planck Institute of Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.
  • Klika Skopic M; TU Dortmund University, Faculty of Chemistry and Chemical Biology, Otto-Hahn-Strasse 6, 44227, Dortmund, Germany.
  • Dos Santos Smith D; TU Dortmund University, Faculty of Chemistry and Chemical Biology, Otto-Hahn-Strasse 6, 44227, Dortmund, Germany.
  • Arendt L; TU Dortmund University, Faculty of Statistics, Vogelpothsweg 87, 44227, Dortmund, Germany.
  • Dormuth I; TU Dortmund University, Faculty of Statistics, Vogelpothsweg 87, 44227, Dortmund, Germany.
  • Adihou H; Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, 43150, Gothenburg, Sweden.
  • Andlovic B; AstraZeneca-Max Planck Institute Satellite Unit, Max-Planck Institute of Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.
  • Karatas H; Lead Discovery Center GmbH (Germany), Otto-Hahn-Strasse 15, 44227, Dortmund, Germany.
  • Shaabani S; Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Den Dolech 2, 5612, AZ, Eindhoven, The Netherlands.
  • Zarganes-Tzitzikas T; Max Planck Institute of Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.
  • Neochoritis CG; University of Groningen, Drug Design, Deusinglaan 1, 7313, AV, Groningen, The Netherlands.
  • Zhang R; University of Groningen, Drug Design, Deusinglaan 1, 7313, AV, Groningen, The Netherlands.
  • Groves M; University of Groningen, Drug Design, Deusinglaan 1, 7313, AV, Groningen, The Netherlands.
  • Guéret SM; University of Crete, Department of Chemistry, 70013, Heraklion, Greece.
  • Ottmann C; University of Groningen, Drug Design, Deusinglaan 1, 7313, AV, Groningen, The Netherlands.
  • Rahnenführer J; University of Groningen, Drug Design, Deusinglaan 1, 7313, AV, Groningen, The Netherlands.
  • Fried R; Medicinal Chemistry, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, 43150, Gothenburg, Sweden.
  • Dömling A; AstraZeneca-Max Planck Institute Satellite Unit, Max-Planck Institute of Molecular Physiology, Department of Chemical Biology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.
  • Brunschweiger A; Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems, Eindhoven University of Technology, Den Dolech 2, 5612, AZ, Eindhoven, The Netherlands.
Angew Chem Int Ed Engl ; 59(46): 20338-20342, 2020 11 09.
Article em En | MEDLINE | ID: mdl-32537835
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / DNA / Proteínas Proto-Oncogênicas c-mdm2 / Peptidomiméticos / Indóis Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / DNA / Proteínas Proto-Oncogênicas c-mdm2 / Peptidomiméticos / Indóis Idioma: En Ano de publicação: 2020 Tipo de documento: Article