Incidence and characteristics of nosocomial influenza in a country with low vaccine coverage.
J Hosp Infect
; 105(4): 619-624, 2020 Aug.
Article
em En
| MEDLINE
| ID: mdl-32540461
ABSTRACT
BACKGROUND:
Influenza vaccination coverage is low in France, in at-risk patients and in healthcare workers.AIM:
We aimed to estimate the incidence of nosocomial influenza, its characteristics and outcome.METHODS:
During one influenza season, we retrospectively evaluated all cases of documented influenza. Inpatients with symptoms onset ≥48 h after admission were enrolled. Data were collected on a standardized questionnaire.RESULTS:
From November 2017 to April 2018, 860 patients tested positive for influenza by polymerase chain reaction analysis on a respiratory sample. Among them, 204 (23.7%) were diagnosed ≥48 h after admission, of whom 57 (6.6% of all influenza cases) fulfilled inclusion criteria for nosocomial influenza 26 women and 31 men, median age 82 years (interquartile range, 72.2-86.9). Twenty patients (38.6%) had recently (<6 months) received the seasonal influenza vaccine. Median time between admission and symptoms onset, and between symptoms onset and diagnosis were, respectively, 11 days (7-19.5) and 29 h (15.5-48). Influenza was mostly acquired in a double-bedded room (N = 39, 68.4%), with documented exposure in 14 cases. Influenza B virus was more common in nosocomial (46/57, 80.7%), than in community-acquired cases (359/803, 44.6%), P<0.001. Mortality rate at three months was 15.8% (N = 9). Incidence of nosocomial influenza was estimated at 0.22 per 1000 hospital-days during the study period.CONCLUSION:
Nosocomial influenza is not rare in elderly inpatients, and may have severe consequences. Influenza B virus was over-represented, which suggests higher transmissibility and/or transmission clusters.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Vacinas contra Influenza
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Infecção Hospitalar
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Cobertura Vacinal
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Influenza Humana
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article