Diagnosing Balamuthia mandrillaris encephalitis via next-generation sequencing in a 13-year-old girl.
Emerg Microbes Infect
; 9(1): 1379-1387, 2020 Dec.
Article
em En
| MEDLINE
| ID: mdl-32552393
ABSTRACT
Balamuthia amoebic encephalitis has a subacute-to-chronic course and is almost invariably fatal owing to delayed diagnosis and a lack of effective therapy. Here, we report a 13-year-old girl with cutaneous lesions and multifocal granulomatous encephalitis. The patient underwent a series of tests and was suspected as having tuberculosis. She was treated with various empiric therapies without improvement. She was finally correctly diagnosed via next-generation sequencing of the cerebrospinal fluid. The patient deteriorated rapidly and died 2 months after being diagnosed with Balamuthia mandrillaris encephalitis. This study highlights the important clinical significance of next-generation sequencing, which provides better diagnostic testing for unexplained paediatric encephalitis, especially that caused by rare or emerging pathogens.
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Base de dados:
MEDLINE
Assunto principal:
Encefalite
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Balamuthia mandrillaris
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Amebíase
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article