Mapping Structural Connectivity Using Diffusion MRI: Challenges and Opportunities.
J Magn Reson Imaging
; 53(6): 1666-1682, 2021 06.
Article
em En
| MEDLINE
| ID: mdl-32557893
ABSTRACT
Diffusion MRI-based tractography is the most commonly-used technique when inferring the structural brain connectome, i.e., the comprehensive map of the connections in the brain. The utility of graph theory-a powerful mathematical approach for modeling complex network systems-for analyzing tractography-based connectomes brings important opportunities to interrogate connectome data, providing novel insights into the connectivity patterns and topological characteristics of brain structural networks. When applying this framework, however, there are challenges, particularly regarding methodological and biological plausibility. This article describes the challenges surrounding quantitative tractography and potential solutions. In addition, challenges related to the calculation of global network metrics based on graph theory are discussed.Evidence Level 5Technical Efficacy Stage 1.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Processamento de Imagem Assistida por Computador
/
Conectoma
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article