Imaging and biodistribution of radiolabeled SP90 peptide in BT-483 tumor bearing mice.
Appl Radiat Isot
; 161: 109162, 2020 Jul.
Article
em En
| MEDLINE
| ID: mdl-32561130
ABSTRACT
The objective of this study was to evaluate radiolabeled DOTA-SP90 as a radiotracer for breast cancer. The in vitro competition assay showed that radiolabeled DOTA-SP90 had significant binding affinity to BT-483 cancer cells. Biodistribution, nanoSPECT/CT and nanoPET/CT imaging results indicated that radiolabeled DOTA-SP90 can accumulate in tumors. In addition, radiolabeled DOTA-SP90 peptides can also detect metastatic tumors. Therefore, radiolabeled SP90 peptide may provide the potential capability as diagnostic agent for breast cancer patients.
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MEDLINE
Assunto principal:
Oligopeptídeos
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Neoplasias da Mama
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Radioisótopos de Índio
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Compostos Radiofarmacêuticos
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Radioisótopos de Gálio
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article