Your browser doesn't support javascript.
loading
Imaging and biodistribution of radiolabeled SP90 peptide in BT-483 tumor bearing mice.
Lo, Wei-Lin; Liang, Chen-Hsien; Chen, Liang-Cheng; Lee, Shih-Ying; Lo, Sheng-Nan; Chen, Ming-Wei; Lu, Ruei-Min; Liu, I-Ju; Wu, Han-Chung; Chang, Chih-Hsien.
Afiliação
  • Lo WL; Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan, Taiwan.
  • Liang CH; Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan, Taiwan.
  • Chen LC; Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan, Taiwan.
  • Lee SY; Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan, Taiwan.
  • Lo SN; Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan, Taiwan.
  • Chen MW; Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan, Taiwan.
  • Lu RM; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan.
  • Liu IJ; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan.
  • Wu HC; Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan.
  • Chang CH; Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan, Taiwan. Electronic address: chchang@iner.gov.tw.
Appl Radiat Isot ; 161: 109162, 2020 Jul.
Article em En | MEDLINE | ID: mdl-32561130
ABSTRACT
The objective of this study was to evaluate radiolabeled DOTA-SP90 as a radiotracer for breast cancer. The in vitro competition assay showed that radiolabeled DOTA-SP90 had significant binding affinity to BT-483 cancer cells. Biodistribution, nanoSPECT/CT and nanoPET/CT imaging results indicated that radiolabeled DOTA-SP90 can accumulate in tumors. In addition, radiolabeled DOTA-SP90 peptides can also detect metastatic tumors. Therefore, radiolabeled SP90 peptide may provide the potential capability as diagnostic agent for breast cancer patients.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Neoplasias da Mama / Radioisótopos de Índio / Compostos Radiofarmacêuticos / Radioisótopos de Gálio Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Neoplasias da Mama / Radioisótopos de Índio / Compostos Radiofarmacêuticos / Radioisótopos de Gálio Idioma: En Ano de publicação: 2020 Tipo de documento: Article