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PDE5 and PDE10 inhibition activates cGMP/PKG signaling to block Wnt/ß-catenin transcription, cancer cell growth, and tumor immunity.
Piazza, Gary A; Ward, Antonio; Chen, Xi; Maxuitenko, Yulia; Coley, Alex; Aboelella, Nada S; Buchsbaum, Donald J; Boyd, Michael R; Keeton, Adam B; Zhou, Gang.
Afiliação
  • Piazza GA; Drug Discovery Research Center, Department of Pharmacology, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA. Electronic address: gpiazza@health.southalabama.edu.
  • Ward A; Drug Discovery Research Center, Department of Pharmacology, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA.
  • Chen X; Drug Discovery Research Center, Department of Pharmacology, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA.
  • Maxuitenko Y; Drug Discovery Research Center, Department of Pharmacology, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA.
  • Coley A; Drug Discovery Research Center, Department of Pharmacology, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA.
  • Aboelella NS; Georgia Cancer Center, Augusta University, Augusta, GA, USA.
  • Buchsbaum DJ; Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, AL, USA.
  • Boyd MR; ADT Pharmaceuticals LLC, Orange Beach, AL, USA.
  • Keeton AB; Drug Discovery Research Center, Department of Pharmacology, Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA.
  • Zhou G; Georgia Cancer Center, Augusta University, Augusta, GA, USA.
Drug Discov Today ; 25(8): 1521-1527, 2020 08.
Article em En | MEDLINE | ID: mdl-32562844
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Fosfodiesterase / Sulindaco / Anti-Inflamatórios não Esteroides / Neoplasias / Antineoplásicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Fosfodiesterase / Sulindaco / Anti-Inflamatórios não Esteroides / Neoplasias / Antineoplásicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article