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Stable HEV IgG seroprevalence in Belgium between 2006 and 2014.
Ho, Erwin; Schenk, Julie; Hutse, Veronik; Suin, Vanessa; Litzroth, Amber; Blaizot, Stéphanie; Herzog, Sereina A; Verburgh, Vera; Jacques, Marjorie; Rahman, Abbas; Michielsen, Peter; Van Damme, Pierre; Van Gucht, Steven; Theeten, Heidi; Hens, Niel; Vanwolleghem, Thomas.
Afiliação
  • Ho E; Department of Gastroenterology and Hepatology, Antwerp University Hospital, Edegem, Belgium.
  • Schenk J; Laboratory of Experimental Medicine and Paediatrics, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
  • Hutse V; Interuniversity Institute for Biostatistics and statistical Bioinformatics, Data Science Institute, Hasselt University, Hasselt, Belgium.
  • Suin V; Centre for Health Economic Research and Modelling Infectious Diseases, Vaccine & Infectious Disease Institute, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
  • Litzroth A; Scientific Directorate Infectious Diseases in Humans, National Reference Centre for Hepatitis Viruses, Sciensano, Belgium.
  • Blaizot S; Scientific Directorate Infectious Diseases in Humans, National Reference Centre for Hepatitis Viruses, Sciensano, Belgium.
  • Herzog SA; Scientific Directorate Epidemiology and Public Health, Sciensano, Belgium.
  • Verburgh V; Centre for Health Economic Research and Modelling Infectious Diseases, Vaccine & Infectious Disease Institute, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
  • Jacques M; Centre for Health Economic Research and Modelling Infectious Diseases, Vaccine & Infectious Disease Institute, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
  • Rahman A; Scientific Directorate Infectious Diseases in Humans, National Reference Centre for Hepatitis Viruses, Sciensano, Belgium.
  • Michielsen P; Scientific Directorate Infectious Diseases in Humans, National Reference Centre for Hepatitis Viruses, Sciensano, Belgium.
  • Van Damme P; Centre for the Evaluation of Vaccination, Vaccine & Infectious Disease Institute, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
  • Van Gucht S; Department of Gastroenterology and Hepatology, Antwerp University Hospital, Edegem, Belgium.
  • Theeten H; Laboratory of Experimental Medicine and Paediatrics, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
  • Hens N; Centre for the Evaluation of Vaccination, Vaccine & Infectious Disease Institute, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
  • Vanwolleghem T; Scientific Directorate Infectious Diseases in Humans, National Reference Centre for Hepatitis Viruses, Sciensano, Belgium.
J Viral Hepat ; 27(11): 1253-1260, 2020 11.
Article em En | MEDLINE | ID: mdl-32564516
Recent European studies suggest an emergence of hepatitis E virus (HEV) infection. We evaluated trends in birth cohort-specific HEV seroprevalence and regional differences in Belgium. HEV IgG seroprevalence was analysed on national serum banks (1579 and 2087 samples for 2006 and 2014, respectively. Hepatitis E virus antigen was tested on positive samples. Observed data were modelled using a generalized additive model with a complementary log-log link. No significant differences between birth cohorts or sexes were found. Modelling identified the individual's age and province as relevant factors. The probability of HEV seropositivity increases significantly with age. An estimated total of 434 819 (yearly rate of 54,352) (sero-)infections were found between 2006 and 2014. Overall, HEV IgG seroprevalences were 4.1% (64/1579, 95% CI 3.1-5.1) and 5.8% (121/2087, CI 4.8-6.9) in 2006 and 2014, respectively. Observed HEV antigen seroprevalence was 0.027% (1/3666) for the entire cohort. These results show stable HEV IgG seroprevalence in Belgium.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus da Hepatite E / Hepatite E Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vírus da Hepatite E / Hepatite E Idioma: En Ano de publicação: 2020 Tipo de documento: Article