[The outcome and safety of neoadjuvant PD-1 blockade plus chemotherapy in stage â
¡~â
¢ non-small cell lung cancer].
Zhonghua Zhong Liu Za Zhi
; 42(6): 480-485, 2020 Jun 23.
Article
em Zh
| MEDLINE
| ID: mdl-32575944
ABSTRACT
Objective:
To explore the safety and therapeutic effect of programmed death 1 (PD-1) antibody combined with chemotherapy as a neoadjuvant therapy for patients with stage â ¡ to â ¢ non-small cell lung cancer (NSCLC).Methods:
Thirteen patients, who had been diagnosed as stage â ¡-â ¢ NSCLC and received PD-1 inhibitor plus chemotherapy as a neoadjuvant treatment in National Cancer Center/Cancer Hospital were recruited. The patients received consecutive neoadjuvant chemotherapy for 21 days as a cycle and the therapeutic efficacy was evaluated after two cycles.Results:
At the last time of follow-up on December 2, 2019, the objective response rate (ORR) and disease control rate (DCR) of these patients were 61.5% (95% CI 30.9%-92.1%) and 100%, respectively. The downregulation rate of disease stage was 61.5% (8/13). The resectable rate was 38.5% (5/13), among them, the major pathologic response (MPR) was 60.0% (3/5) and the complete pathologic response (CPR) was 20.0% (1/5). The neoadjuvant chemotherapy displayed a low incidence of adverse reaction. The main grade 3 to 4 toxicities were neutropenia (38.5%) and leukopenia (23.1%). There was no significant immune-related toxicity. The safety and tolerability of perioperative period of patients underwent resection were promising.Conclusions:
Immunotherapy combined with chemotherapy as a neoadjuvant treatment is an effective, low-toxicity treatment manner, which has perioperative safety and high rate of MPR for patients with resectable NSCLC. It is a promising treatment option for patients with stage â ¡ to â ¢ NSCLC.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Protocolos de Quimioterapia Combinada Antineoplásica
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Carcinoma Pulmonar de Células não Pequenas
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Terapia Neoadjuvante
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Receptor de Morte Celular Programada 1
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Neoplasias Pulmonares
Idioma:
Zh
Ano de publicação:
2020
Tipo de documento:
Article