An octabrominated Sn(iv) tetraisopropylporphyrin as a photosensitizer dye for singlet oxygen biomedical applications.
Dalton Trans
; 49(28): 9568-9573, 2020 Jul 21.
Article
em En
| MEDLINE
| ID: mdl-32578634
ABSTRACT
Two novel Sn(iv) tetraisopropylphenylporphyrins have been synthesized to explore the effect of octabromination at the ß-pyrrole positions on their photophysical properties and photodynamic activity. The lower energy Q band of an octabrominated complex lies at 675 nm well within the therapeutic window. The octabrominated dye has a relatively high singlet oxygen quantum yield of 0.78 in DMF and exhibits favorable photodynamic activity against MCF-7 cells with an IC50 value of 10.7 µM and a 5.74 log reduction value (5 µM) towards S. aureus under illumination at 660 nm for 60 min with a Thorlabs M660L3 LED (280 mW cm-2).
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Base de dados:
MEDLINE
Assunto principal:
Fotoquimioterapia
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Fármacos Fotossensibilizantes
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Oxigênio Singlete
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Antineoplásicos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article