The Flavonoid Agathisflavone from Poincianella pyramidalis Prevents Aminochrome Neurotoxicity.
Neurotox Res
; 38(3): 579-584, 2020 Oct.
Article
em En
| MEDLINE
| ID: mdl-32588357
ABSTRACT
Flavonoids have been suggested to protect dopaminergic neurons in Parkinson's disease based on studies that used exogenous neurotoxins. In this study, we tested the protective ability of agathisflavone in SH-SY5Y cells exposed to the endogenous neurotoxin aminochrome. The ability of aminochrome to induce loss of lysosome acidity is an important mechanism of its neurotoxicity. We demonstrated that the flavonoid inhibited cellular death and lysosomal dysfunction induced by aminochrome. In addition, we demonstrated that the protective effect of agathisflavone was suppressed by antagonists of estrogen receptors (ERα and ERß). These results suggest lysosomal protection and estrogen signaling as mechanisms involved in agathisflavone neuroprotection in a Parkinson's disease study model.
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Base de dados:
MEDLINE
Assunto principal:
Morte Celular
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Síndromes Neurotóxicas
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Biflavonoides
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Neurônios Dopaminérgicos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article