A near-infrared light-controlled, ultrasensitive one-step photoelectrochemical detection of dual cell apoptosis indicators in living cancer cells.
Chem Commun (Camb)
; 56(60): 8488-8491, 2020 Jul 28.
Article
em En
| MEDLINE
| ID: mdl-32588858
ABSTRACT
Here, a near-infrared (NIR) light-controlled, ultrasensitive one-step photoelectrochemical (PEC) strategy was constructed to simultaneously detect cell apoptosis indicators, phosphatidylserine (Pho) and sodium-potassium adenosine triphosphatase (Sat), on living cancer cells. Using NIR light as excitation, the signal probe methylene blue (Tagkinetic) could be released, leading to a gradually decreased photocurrent signal Ikinetic; meanwhile, the photocurrent Istable of the signal probe carbon quantum dots (Tagstable) remained stable. The simultaneous detection of Pho and Sat could be achieved based on rapid one-step PEC detection under single NIR light with the assistance of a smart signal decryption strategy with Ikinetic and Istable. Importantly, this proposal provides more effective drug candidates with milder pharmaceutical effect but improved safety.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fosfatidilserinas
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Apoptose
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ATPase Trocadora de Sódio-Potássio
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Técnicas Eletroquímicas
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Raios Infravermelhos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article