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Merger of C-F and C-N Bond Cleavage in Cross-Electrophile Coupling for the Synthesis of gem-Difluoroalkenes.
Jin, Youxiang; Wu, Jiaoyang; Lin, Zhiyang; Lan, Yun; Wang, Chuan.
Afiliação
  • Jin Y; Hefei National Laboratory for Physical Science at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.
  • Wu J; Hefei National Laboratory for Physical Science at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.
  • Lin Z; Hefei National Laboratory for Physical Science at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.
  • Lan Y; Hefei National Laboratory for Physical Science at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.
  • Wang C; Hefei National Laboratory for Physical Science at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.
Org Lett ; 22(14): 5347-5352, 2020 07 17.
Article em En | MEDLINE | ID: mdl-32589040
ABSTRACT
Herein we successfully applied Katritzky salts as the alkyl electrophile in the reductive allylic defluorinative cross-coupling reaction with α-trifluoromethyl alkenes. The merger of C-F and C-N bond cleavage via the synergistic effect of nickel and zinc allows the efficient synthesis of diverse gem-difluoroalkenes with a good tolerance for various functional groups.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article