NRF2 pathway activation by KEAP1 inhibition attenuates the manifestation of aging phenotypes in salivary glands.

Wati, Sisca Meida; Matsumaru, Daisuke; Motohashi, Hozumi

Wati, Sisca Meida; Matsumaru, Daisuke; Motohashi, Hozumi.

Afiliação

Wati SM; Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University, Japan.
Matsumaru D; Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University, Japan.
Motohashi H; Department of Gene Expression Regulation, Institute of Development, Aging and Cancer, Tohoku University, Japan. Electronic address: hozumim@med.tohoku.ac.jp.

Redox Biol ; 36: 101603, 2020 09.

Article em En | MEDLINE | ID: mdl-32590331

Assuntos

Fator 2 Relacionado a NF-E2; Estresse Oxidativo; Envelhecimento/genética; Animais; Proteína 1 Associada a ECH Semelhante a Kelch/genética; Camundongos; Fator 2 Relacionado a NF-E2/genética; Fator 2 Relacionado a NF-E2/metabolismo; Fenótipo; Glândulas Salivares/metabolismo

Palavras-chave

Aging; KEAP1; Mouse; NRF2; Salivary glands

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estresse Oxidativo / Fator 2 Relacionado a NF-E2 Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estresse Oxidativo / Fator 2 Relacionado a NF-E2 Idioma: En Ano de publicação: 2020 Tipo de documento: Article